Table 2 Diagnostic performance of the combination of CRP, Fcal and LRG for endoscopic remission
Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) | AUC (95% CI) | |
|---|---|---|---|---|---|---|
Combination of 2 markers | ||||||
CRP (-) and LRG (-) | 74.2% (66.3–82.0) | 90.0% (84.4–95.6) | 89.0% (82.9–95.1) | 76.2% (68.8–83.5) | 81.7% (76.7–86.7) | 0.831 (0.7823–0.879) |
CRP (-) and Fcal (-) | 69.0% (60.5–77.4) | 93.9% (89.5–98.3) | 92.0% (86.2–97.7) | 74.8% (67.7–81.9) | 81.3% (76.3–86.3) | 0.814 (0.764–0.864) |
Fcal (-) and LRG (-) | 65.5% (56.9–74.2) | 97.4% (94.4–1.00) | 96.2% (92.0–1.00) | 73.5% (66.5–80.5) | 81.3% (76.3–86.3) | 0.814 (0.764–0.864) |
Combination of 3 markers | ||||||
Two or more markers (-) of the 3 markers | 89.4% (83.5–95.3) | 83.3% (76.8–89.8) | 81.6% (74.5–88.7) | 90.5% (85.2–95.8) | 86.1% (81.6–90.6) | 0.860 (0.816–0.905) |
CRP (-), Fcal (-), and LRG (-) | 71.3% (64.2–78.3) | 100% (100–100) | 100% (100–100) | 60.3% (51.4–69.2) | 80.0% (74.8–85.1) | 0.794 (0.742–0.846) |