Table 3 Validation of the predictive diagnostic ability of the 3 markers supported by k-fold cross-validation
Sensitivity (95% CI) | Specificity(95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) | AUC (95% CI) | P-value (95% CI) | |
|---|---|---|---|---|---|---|---|
The 3-marker method (two or more markers (-)of the 3 markers) | 89.7 (82.6–94.5) | 80.7% (72.3–87.5) | 82.5% (74.8–88.7) | 88.5% (80.7–93.9) | 85.2% (80.0–89.5) | 0.852 (0.806–0.898) | |
All three markers negative (CRP (-), Fcal (-), and LRG (-)) | 56.9 (47.4–66.1) | 100.0% (96.8–100.0) | 100.0% (94.6–100.0) | 69.5% (61.9–76.5) | 78.3% (72.4–83.4) | 0.785 (0.739–0.830) | 0.0190 |
CRP (-) and Fcal (-) | 67.2 (57.9–75.7) | 93.9% (87.8–97.5) | 91.8% (83.8–96.6) | 73.8% (65.8–80.7) | 80.4% (74.7–85.4) | 0.806 (0.757–0.854) | 0.0654 |
Fcal (-) and LRG (-) | 63.8 (54.4–72.5) | 96.5% (91.3–99.0) | 94.9% (87.4–98.6) | 72.4% (64.5–79.3) | 80.0% (74.2–85.0) | 0.801 (0.754–0.849) | 0.0589 |
CRP (-) and LRG (-) | 72.4 (63.3–80.3) | 90.4% (83.4–95.1) | 88.4% (80.2–94.1) | 76.3% (68.2–83.2) | 81.3% (75.7–86.1) | 0.814 (0.765–0.863) | 0.0906 |