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Table 2 Correlation of clinicopathological characteristics and NLR(or PLR) levels in rectal cancer

From: Association of clinicopathological factor with lymph node metastasis in rectal cancer patients: a retrospective cohort study

Viable

NLR(n,%)

 

P

 

PLR(n,%)

P

 

H- NLR

(38,21.0%)

L- NLR

(143,79.0%)

 

H-PLR

(153,84.5%)

L-PLR

(28,15.5%)

 

Age(y)

  

0.418

  

0.796

 ≥65

19(50.0%)

61(42.7%)

 

67(43.8%)

13(46.4%)

 

 <65

19(50.0%)

82(57.3%)

 

86(56.2%)

15(53.6%)

 

Sex

     

0.826

 Male

22(57.9%)

91(63.6%)

0.320

95(62.1%)

18(64.3%)

 

 Female

16(41.1%)

52(36.4%)

 

58(37.9%)

10(35.7%)

 

Location

(cm)

  

0.577

  

0.888

 ≥ 5

29(76.3%)

115(80.4%)

 

122(79.7%)

22(78.6%)

 

 < 5

9(23.7%)

28(19.6%)

 

31(20.3%)

6(21.4%)

 

TNM

  

0.515

  

0.003*c

 I

6(15.8%)

32(22.4%)

 

29(19.0%)

9(32.1%)

 

 II

11(28.9%)

46(32.2%)

 

43(28.1%)

14(50%)

 

 III

21(55.3%)

65(45.4%)

 

81(52.9%)

5(17.9%)

 

PNI

  

0.442

  

0.004*

 Negative

17(44.7%)

74(51.7%)

 

70(45.8%)

21(75.0%)

 

 Positive

21(55.3%)

69(48.3%)

 

83(54.2%)

7(25.0%)

 

LVI

  

0.172

  

0.025*

 Negative

16(42.1%)

78(54.5%)

 

74(48.4%)

20(71.4%)

 

 Positive

22(57.9%)

65(45.5%)

 

79(51.6%)

8(28.6%)

 

TDs

  

0.730a

  

0.028*a

 Negative

34(89.5%)

125(87.4%)

 

131(85.6%)

28(100%)

 

 Positive

4(10.5%)

18(12.6%)

 

22(14.4%)

0(0%)

 

Lymph nodes metastasis

  

0.361

  

< 0.001*

 No

17(44.7%)

78(54.5%)

 

72(47.1%)

23(82.1%)

 

 Yes

21(55.3%)

65(45.5%)

 

81(52.9%)

5(17.9%)

 

TLN(median, IQR)

19.5

(15.0−24.7)

18

(14.0–22.0)

0.227b

18.0(15.0–22.0)

18.5(14.0–20.0)

0.283b

CEA(ng/ml)

  

0.853

  

0.005*

 ≥5

14(36.8%)

56(39.2%)

 

66(43.1%)

4(14.3%)

 

 <5

24(63.2%)

87(60.8%)

 

87(56.9%)

24(85.7%)

 

CA199

(ng/ml)

  

0.823

  

0.800

 ≥27

8(21.1%)

28(19.6%)

 

30(19.6%)

6(21.4%)

 

 <27

30(78.9%)

115(80.4%)

 

123(80.4%)

22(78.6%)

 
  1. Data are presented as n (%),Bolded p-values indicate statistical significance at p < 0.05
  2. Abbreviations: LVI: lymphovascular invasion; PNI: perineural invasion; CEA: carcinoembryonic antigen TDs: tumor deposits;
  3. TNM: tumor node metastasis; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio
  4. TLN: total lymphnode number; IQR: interquartile range
  5. using Fisher’s exact test or chi-squared test for categorical variables
  6. a P-value was estimated by the Fisher Exact test
  7. b P-value was estimated by Mann-Whitney U test