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Table 4 Logistic regression analysis of the relationship between lymph node metastasis and clinicopathological characteristics in rectal cancer patients

From: Association of clinicopathological factor with lymph node metastasis in rectal cancer patients: a retrospective cohort study

Viable

Univariate Analysis

OR (95% CI)

P

Multivariate Analysis

OR (95% CI)

P

Age(y)

 

0.261

  

 ≥ 65

Ref.

   

 < 65

0.712(0.394–1.287)

   

gender

 

0.409

  

 male

Ref.

   

 female

1.289(0.706–2.356)

   

location

 

0.094

  

 ≥ 5 cm

Ref.

   

 < 5 cm

0.527(0.249–1.115)

   

T stage

 

0.001*

 

0.604

 T1−2

Ref.

 

Ref.

 

 T3−4

3.156(1.580–6.303)

 

1.272(0.512–3.157)

 

PNI

 

< 0.001*

 

0.008*

 Negative

Ref.

 

Ref.

 

 Positive

6.182(3.242–11.787)

 

3.086(1.341–7.102)

 

LVI

 

< 0.001*

 

< 0.001*

 Negative

Ref.

 

Ref.

 

 Positive

10.271(5.177–20.375)

 

6.203(2.892–13.303)

 

NLR

 

0.283

  

 L-NLR

Ref.

   

 H-NLR

1.482(0.722–3.043)

   

PLR

 

0.002*

 

0.063

 L-PLR

Ref.

 

Ref.

 

 H-PLR

5.175(1.870−14.321)

 

3.146(0.939–10.538)

 

TDs

 

0.016*

 

0.831

 Negative

Ref.

 

Ref.

 

 Positive

3.390(1.261–9.117)

 

1.142(0.337–3.869)

 

TLN

1.053(1.005–1.103)

0.030*

1.016(0.958–1.078)

0.593

CEA

(ng/mL)

 

< 0.001*

 

0.204

 <5

Ref.

 

Ref.

 

 ≥5

3.313(1.655–5.920)

 

1.684(0.754–3.761)

 

CA199

(ng/mL)

 

0.047*

 

0.066

 <27

Ref.

 

Ref.

 

 ≥27

2.248(1.012–4.992)

 

2.529(0.940–6.804)

 
  1. Abbreviations: LVI: lymphovascular invasion; PNI: perineural invasion; CEA: carcinoembryonic antigen TDs: tumor deposits;
  2. NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; OR: odd risk
  3. TLN: total lymphnode number
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BMC Gastroenterology

ISSN: 1471-230X

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