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Fig. 1 | BMC Gastroenterology

Fig. 1

From: Effect of pemafibrate in reducing intestinal long-chain fatty acid absorption and hepatic fibrosis in metabolic dysfunction-associated steatohepatitis rats

Fig. 1

Pemafibrate inhibits postprandial fatty acid absorption in the small intestine of MASH model rats. (a) Experimental protocol. To evaluate postprandial intestinal fat absorption, a single dose of pemafibrate or vehicle was administered with olive oil, and fecal samples were collected 24 h later. (b) Serum NEFA levels in the pemafibrate (-) and pemafibrate (+) groups. (c) Coefficient of intestinal lipid absorption in the pemafibrate (-) and pemafibrate (+) groups. N = 5 per group; *P < 0.05. Data in the bar plots are expressed as mean ± standard deviation. Significant differences were determined using the Mann–Whitney U-test. (d) Representative images of the jejunum tissue stained with Oil Red O in the pemafibrate (-) and pemafibrate (+) groups. Top: magnification, 100×; scale bar, 200 μm. Bottom: magnification, 200×; scale bar: 100 μm (bottom)

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BMC Gastroenterology

ISSN: 1471-230X

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